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Definition. Three main phenotypes describe HF according to the measurement of the left ventricle ejection fraction (EF), and the differentiation between these types is important due to different demographics, comorbidities, and responses to therapies: Heart failure with reduced ejection fraction (HFrEF): EF less than or equal to .
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Van Rooj et. al. demonstrated that the inhibition of miR-208a by systemic delivery of locked nucleic acid–modified antisense oligonucleotide prevented cardiac remodeling in a rat model of LV failure. This technology also prevented pathological myosin switching and cardiac remodeling, while improving cardiac function .
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